Equivalent Study Sample Size. Your sample size or power calculation for clinical trials depends on your trial design. In order to estimate the sample size we need approximate values of p 1 and p 2.
M2 m1 versus Ha. Thus if there is no information available to approximate p 1 and p 2 then 05 can be used to generate. For an equivalence assessment we would wish.
Al2005 and Wang and Chow 2002.
Researchers want to show that a new treatment is equivalent to the standard one. Therefore it is reasonable to assume that if your sample is 30 or greater your mean has a normal distribution with sample variance equal to population variance divided by sample size sigma2n. 1 β 2 Φ z z 1 α Φ z z 1 α 1 z p A p B δ p A 1 p A n A p B 1 p B n B. The standard and novel treatments is less than or equal to D indicating equivalence.
